Data from: Synthesis of 4-substituted ethers of Benzophenone and their antileishmanial activity

Leishmaniasis is a vector born protozoan disease, it is mainly originated by the bite of sand fly and initiated when parasite is transmitted to human at the stage of metacyclic flagellated promastigote form. In current study, a synthesis of a series of 4-substituted benzophenone ethers 1-20 has been carried out in good yields and their in vitro antileishmanial activity has also been performed. Among synthetic derivatives, fifteen compounds 1, 3, 5-12, 15, and 17-20 showed antilieshmanial activity against promastigotes of Leishmania major with IC50 values in the range of 1.19 - 82.30 µg/mL, and compared with the standard pentamidine (IC50 = 5.09 ± 0.09 µg/mL). This study identified a series of new antileishmanial molecules as potential lead. Structures of these synthetic compounds were deduced by different spectroscopic techniques such as 1H-NMR, 13C-NMR, EI-MS, HREI-MS, and IR.