Ternary complex of a charged molecular glue degrader ZZ1-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26

Ternary complex of a charged molecular glue degrader ZZ1-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26 Descriptor: 2-chloranyl-4-[[4-[(9S)-4,5,13-trimethyl-9-[2-[(2-methylpropan-2-yl)oxy]-2-oxidanylidene-ethyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-7-yl]phenyl]carbamoyl]benzenesulfinic acid, Bromodomain-containing protein 4, Protein yippee-like 5, ... Authors: Chrustowicz, J, Schulman, B.A. Deposit date: 2025-07-01 Release date: 2026-04-08 Last modified: 2026-04-29 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Charged molecular glue discovery enabled by targeted degron display. Nat.Chem.Biol., 2026