We characterised genome-wide mutations induced by the O6-dG-methylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in mouse embryonic fibroblasts, deficient for the Pol ? catalytic subunit REV3
During DNA replication, mutations occur when an incorrect dNTP is incorporated opposite a carcinogen-modified nucleotide. We have probed the structures of the interaction between O 6-methylguanine ( O
