Data from: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks

The data in this collection relates to the publication titled “Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks”, authored by Wright, Leger, et al. The majority of the collection is dedicated to the phenotypic and genetic data presented in figure two of the manuscript, and for related traits collected for this study. This collection also included raw phenotypic measurements for each of the 6,147 rats used in this study. GWAS data was collected and analyzed as described in “Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose” by Chitre et al., 2020 in continuation of this study. Additionally, this collection contains genotype data collected as part of the NIDA Center for GWAS in Outbred rats and more than 10 additional research projects that use N/NIH heterogeneous stock (HS) outbred rats. We obtain genotypes for DNA samples derived from rats that are phenotyped by different research projects. We use these genotypes to perform genome wide association studies (GWAS) and a number of related analyses.

本数据集内容与标题为“人类与大鼠全基因组关联研究：在突触、表观遗传组和激素信号通路中趋同”的出版物相关，该文由Wright、Leger等作者所著。数据集的大部分内容专注于论文中图二所展示的表型和遗传数据，以及为该研究收集的相关性状数据。此外，本数据集还包含了用于本研究中的6,147只大鼠的原始表型测量数据。全基因组关联研究（GWAS）数据按照Chitre等人在2020年发表的《在3,173只近交大鼠中进行全基因组关联研究：鉴定体重、肥胖和空腹血糖的多个位点》一文中的描述进行收集和分析，以延续该研究。此外，本数据集还包含了作为NIDA中心全基因组关联研究在外来大鼠中的研究部分所收集的基因型数据，以及超过10个使用N/NIH异质股票（HS）外来大鼠的研究项目。我们从由不同研究项目表型的老鼠中提取的DNA样本中获取基因型。我们利用这些基因型进行全基因组关联研究（GWAS）以及一系列相关分析。