Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.
收藏PubMed Central1993-08-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC47143/
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资源简介：
The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the total colonies formed in culture from fractionated vibrissae were in this location and fewer than 4% were located in the matrix area of the follicle. Finer dissection of the bulge-containing region located the colony-forming cells in the small part containing the bulge itself. The segregation of keratinocyte colony-forming cells in the bulge confirms the hypothesis that the bulge is the reservoir of the stem cells responsible for the long-term growth of the hair follicle and perhaps of the epidermis as well. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-08-01
