Whole exome and RNASeq profiling of patients with both well differentiated and de-differentiated liposarcoma. Genomic profiling of matched well differentitated and de-differentiated liposarcoma

Well-differentiated (WD) liposarcoma is a low-grade mesenchymal tumor with features of mature adipocytes and high propensity for local recurrence. WD can often co-occur or later progress to a high grade tumor called dedifferentiated (DD) liposarcoma that no longer looks like fat tissue, behaves more aggressively and can metastasize. The genomic alterations that occur during progression from WD to DD tumors are not be well-described. Therefore, we selected patients who presented with both WD and DD tumors for extensive genomic profiling in order to understand their clonal relationships and to delineate any defining alterations for each entity.