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Transcriptome Analysis of TubA Effects on Oocytes Development in Mice. Transcriptome Analysis of TubA Effects on Oocytes Development in Mice

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA557119
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TubA is a specific inhibitor of HDAC6, it could regulate oocytes maturation by regulating acetylation of α-tubulin. However, weather it effects maternal mRNA expression remains unkown. Therefore, in this study,we got in vitro maturated MII oocytes in control and 0.1μg/mL treated .Our study suggests that TubA mainly downregulated cell cycle and DNA methylation related genes. Overall design: single cell mRNA profiles of control and TubA treated MII oocytes were generated by deep sequencing, 5 samples for each group, using Illumina HiSeq 2000
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2019-07-29
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