Transcriptomic profile of non-alcoholic fatty liver disease in rat induced by high-fat diet

This study aimed to investigate the effect and underlying mechanism of Smilax china L. Saponins (SCS) on lipid metabolic disturbance in rats with non-alcoholic fatty liver disease (NAFLD). Rats were administrated with a high-fat diet (HFD) for 8 weeks to induce NAFLD, followed by SCS treatment for further 8 weeks. Overall design: Rats were randomly devided into three groups, including normal group, model group (high-fat diets for 8 weeks) and SCS group