Fold differences in IC50 values obtained for HG-7-85-01-treated MOLM13-R-PKC412 cells cultured in the presence and absence of PKC412 prior to assay.

MOLM13-R-PKC412 cells were either in the continuous presence of PKC412 prior to treatment with HG-7-85-01 (PKC412 was washed out on the day of the set up of the proliferation study), or they were cultured according to the following treatment conditions: Condition #1: Two-day withdrawal of PKC412 from MOLM13-R-PKC412 cells prior to assay. Condition #2: Two days of PKC412 treatment of MOLM13-R-PKC412, two days of PKC412 withdrawal, three days of PKC412 treatment, and two days of PKC412 withdrawal prior to assay. Condition #3: Five days of PKC412 withdrawal prior to assay. Condition #4: Seven days of PKC412 withdrawal prior to assay. IC50 values are presented as fold increases over IC50 obtained for HG-7-85-01 against MOLM13-S cells.