Crystal structure of human PHGDH in complex with Homoharringtonine
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Crystal structure of human PHGDH in complex with Homoharringtonine Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, D-3-phosphoglycerate dehydrogenase Authors: Hsieh, C.H, Cheng, Y.S, Lee, Y.S, Huang, H.C, Juan, H.F. Deposit date: 2021-05-25 Release date: 2022-12-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma. Biomed Pharmacother, 166, 2023
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2021-05-25
