Long noncoding RNA <i>ENST00000508435</i> promotes migration of breast cancer via FXR 1

LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, <i>ENST00000508435</i>, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of <i>ENST00000508435</i> was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of <i>ENST00000508435</i> significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that <i>ENST00000508435</i> could directly bind to FXR1 to promote tumor metastasis. <i>ENST00000508435</i> and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that <i>ENST00000508435</i> regulates FXR1 to promote breast cancer metastasis.