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Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP424913
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To investigate the influence of Serpin E2 (aka PN-1) on glia in the brain, we purified microglia and astrocytes and performed RNA sequencing from Serpine2-/- mice Overall design: Microglia or astrocytes were purified from the brain of adult Serpine2-/- mice and littermates with at least one functional Serpine2 allele. Half of the sibling pairs were injected with lipopolysaccharides and others received saline injections.
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2026-02-02
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