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Integrated analyses of histone methylation and RNA expression in beta cells sorted from mice with multiparity-induced diabetes identified effector genes of pancreatic beta cell dedifferentiation and dysfunction.

NIAID Data Ecosystem2026-03-11 收录

糖尿病β细胞机制

转录组与表观遗传学

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130998 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2019-06-01

红系祖细胞自我更新调控

转录组与表观遗传学

RNA-Seq was utilized to monitor changes of gene expression profile of BFU-E cultured with DMSO, compound OB or PD; ChIP-Seq was utilized to identify binding sites of CREB in BFU-E Overall design: BFU-

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Microarray was used to detect the expression of lncRNAs and mRNAs in INS-1 cells treated with GLP-1RA Geniposide for 24 hours.

糖尿病β细胞机制

RNA调控网络

Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in various physiological and pathological processes. In recent years, there have been many studies on GLP-1 receptor agonis

NIAID Data Ecosystem20

Genetic and epigenetic regulation of mouse pancreatic islets by β-cell-specific ablation or overexpression of BAF60a

细胞功能调控

转录组与表观遗传学

In this study, we used multiple mouse models and sequencing techniques to assess the effects of beta-cell-specific ablation or overexpression of BAF60a (BaβKO or BaOE) in mouse islets. This dataset co

Mendeley Data10

Menin-regulated Pbk controls High fat diet-induced compensatory beta cell proliferation

糖尿病β细胞机制

menin抑制剂治疗

Pancreatic beta cells undergo compensatory proliferation in the early phase of type 2 diabetes. While pathways such as FoxM1 are involved in regulating compensatory beta cell proliferation, given the

NIAID Data Ecosystem20

RNA-seq analysis to examine the effect of KDM2B knockdown or overexpression on transcriptional responses in ECs during VEGF-signaling. RNA-seq analysis to examine the effect of KDM2B knockdown or overexpression on transcriptional responses in ECs during VEGF-signaling

血管生成调控

转录组与表观遗传学

Vascular endothelial growth factor (VEGF) signaling serves a central role in vascular development as well as maintaining vascular homeostasis. In endothelial cells (ECs), VEGF activates gene expressio

NIAID Data Ecosystem10

Integrated analyses of histone methylation and RNA expression in beta cells sorted from mice with multiparity-induced diabetes identified effector genes of pancreatic beta cell dedifferentiation and dysfunction.

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