Estrogen Receptor 1 is a Central Regulator of Hepatocarcinogenesis through Inhibition of Wnt/β-catenin Signaling
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE167175
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A genetic mouse model of HCC was generated through the injection of proto-oncogene-coding plasmids, then given a 5 week treatment of either ESR1 agonist or antagonist. HCC was generated through hydrodynamic tail vein injection of proto-oncogene-coding plasmids in 8-10-week-old Male and Female FVB/N mice; 2 weeks post-injection mice where given a 5-week treatment of the following: 1) ESR1 agonist Propyl pyrazole triol (PTT) subcutaneously at 1mg/kg (Sigma-Aldrich H6036) N=6; 2) ESR1 antagonist methyl-piperidino-pyrazole (MPP) given subcutaneously at 200ug/kg
创建时间：
2021-12-15
