Crystal structure of ADC-227 in the avibactam complex (50 mM for 4 hour)
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Crystal structure of ADC-227 in the avibactam complex (50 mM for 4 hour) Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase Authors: Kawai, A, Doi, Y. Deposit date: 2025-08-29 Release date: 2026-03-25 Last modified: 2026-04-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Val292 substitution combined with an alanine duplication (ADUP) in the Omega loop of ADC beta-lactamase confers reduced susceptibility to advanced beta-lactam agents, including cefiderocol. Mbio, 2026
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2025-08-29
