Indole Diterpene Synthetic Studies: Development of a Second-Generation Synthetic Strategy for (+)-Nodulisporic Acids A and B

A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development
of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald−Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability
of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation
approach.