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Ascl2-dependent cell differentiation drives regeneration of abated intestinal stem cells

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP195807
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资源简介:
Functions of Ascl2 in colonic stem cell maintenance and regeneration. We used RNA-sequencing to profile gene expression in regenerating crypt cells and Ascl2-deficient colonic stem cells, and ASCL2 ChIP-seq to identify transcriptional target genes. Overall design: RNA-seq and ASCL2 ChIP-seq analyses of isolated mouse colonic stem cells. RNA-seq analyses of Ascl2-deficient mouse colonic stem cells. Single Cell RNA-seq analysis of regenerating colonic crypt cells. Transcript dynamics of colonic epithelial development.
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2020-02-29
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