Biomimetic Synthesis of the Tetracyclic Core of Berkelic Acid
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/Biomimetic_Synthesis_of_the_Tetracyclic_Core_of_Berkelic_Acid/3005659
下载链接
链接失效反馈官方服务：
资源简介：
Acid-catalyzed condensation of 2,6-dihydroxybenzoic acid 3 with ketal aldehyde 14 in methanol at 25 °C, followed by CH2N2 esterification,
gave a 4:1:4:1 mixture of diastereomers 15b−18b in 60% yield. Equilibration of this mixture with TFA in CDCl3 provided tetracycle 15b (83%
yield) with the complete skeleton of berkelic acid. A similar condensation at 0 °C afforded 15b−18b and a reduction product 19b, which was
probably formed by a 1,5-hydride shift.
创建时间：
2007-05-24
