Biochemical analysis of manganese-induced changes in the tissue level of monoamines.

Manganese-induced a decrease in the tissue level of NE and 5-HT in the frontal cortex and increase of DA metabolism in the striatum. Tissue contents of DA, DOPAC, HVA, 5-HT, and 5-HIAA in the striatum and NE, 5-HT, and 5-HIAA in the frontal cortex measured by HPLC in manganese-treated rats and their controls. Values are concentrations in ng/g of wet tissue presented as the mean ± SEM. Statistical analysis using Mann–Whitney test was performed; *p<0.05 in comparison with control.