The transcription factor MSX2 partially mediates the effect of bone morphogenetic protein 4 (BMP4) on somatic cell programming
收藏干细胞与再生医学数据中心2021-12-14 更新2024-03-06 收录
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The time- and concentration-dependent effects of BMPs on reprogramming were investigated to be mediated by MSX2. BMPs upregulate Msx2 by activating SMAD1/5, and then MSX2 binds directly to the promoter and upregulates the expression of Cdh1, Gata3 and Nanog genes. cdh1 contributes to BMP4- and MSX2-induced MET and subsequently promotes reprogramming. On the other hand, GATA3 promotes reprogramming, probably by upregulating SALL4 expression.
提供机构：
中国科学院广州生物医学与健康研究院
创建时间：
2021-12-14
