Parameter optimization for generation of consensus helix architectures.

aContact threshold (NN4/NN4-D): number of required helix-helix contacts to predict a helix as interacting. NN4 and NN4-D are two versions of the TMHcon software for the prediction of helix-helix contacts.bConsensus threshold: fraction of individual helix architectures required to contain a helix interaction to transfer it to the consensus architecture.cSensitivity: fraction of known interacting helices that can also be found in the predicted architectures.dSpecificity: fraction of known non-interacting helices that are also absent in the predicted architectures.ePDB: helix architectures derived from known PDB structures were compared with those that were predicted for these PDB proteins.fAverage: helix architectures were predicted for all proteins involved in the consensus architecture and compared with the helix architectures derived from the known PDB structures.