Micro-ED structure of the NSH2-CSH2 tandem domain of SHP2 in complex with the bis-phosphorylated pY627-pY659-Gab1 (613-694) peptide

Micro-ED structure of the NSH2-CSH2 tandem domain of SHP2 in complex with the bis-phosphorylated pY627-pY659-Gab1 (613-694) peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Machner, L, Shaikhqasem, A, Hamdi, F, Breithaupt, C, Parthier, C, Kyrilis, F.L, Kastritis, P.L, Feller, S.M, Stubbs, M.T. Deposit date: 2025-03-04 Release date: 2025-12-31 Last modified: 2026-03-18 Method: ELECTRON CRYSTALLOGRAPHY (3.2 Å) Cite: Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1. Structure, 34, 2026