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Histone H3.3 and its proteolytically processed form drive a cellular senescence program

ChEBI2014-10-01 更新2026-07-21 收录

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细胞衰老机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55949 数据链接链接失效反馈

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Histone H3.3 and its proteolytically processed form drive a cellular senescence program

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创建时间：

2014-10-01

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去泛素化酶

USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA

reactome.org100

Transcriptomic characterization of human primary prostate stromal cells upon exposure to chemotherapy and treatment by a natural flavonoid apigenin

细胞衰老机制

天然抗氧化剂

Senescent cells accumulate in a wide variety of solid tissues of mammalian species with advancing age, functionally promoting chronic inflammation and causing age-related diseases. Apigenin is one of

NIAID Data Ecosystem00

SETD1A protects from senescence through regulation of the mitotic gene expression program

细胞衰老机制

有丝分裂调控

SETD1A, a member of the Set1/COMPASS family maintaining H3K4 methylation in the promoters of transcriptionally active genes, is critical for the execution of developmental gene expression and is overe

NIAID Data Ecosystem00

Profiling of H3K9cr and H3K9ac in the P19 embryonal carcinoma cells

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细胞分化表观遗传学

To gain a deeper insight into dynamic changes of H3K9cr and H3K9ac during cell fate commitment, ChIP-seq was performed to analyze the genome-wide changes of H3K9cr and H3K9ac during neuroectodermal di

NIAID Data Ecosystem60

Metabolic reprogramming in astrocytes prevents neuronal death through a UCHL1/PFKFB3/H4K8la positive feedback loop

脊髓损伤代谢

组蛋白修饰

Astrocytic metabolic reprogramming is an adaptation of metabolic patterns to meet increased energy demands, although the role after spinal cord injury (SCI) remains unclear. Analysis of single-cell RN

NIAID Data Ecosystem00

Histone H3.3 and its proteolytically processed form drive a cellular senescence program

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