Changes in chromatin accessibility assocaiated with CD8 T cell responses to viral infections

The goal of this study was to identify the molecular programming using ATAC-seq of CD8 T cells responding to different viral infections. Mice were infected with either LCMV Armstrong to model an acute infection or LCMV Clone-13 to model a chronic infection. At various time points following infection, virus-specific CD8 T cells were purified and ATAC-seq performed. These data identify the changes in chromatin accessibility associated with acute infections and the establishment of functional memory versus those accessibility changes associated with chronic infection. Overall design: ATAC-seq time course on CD8 T cells following either LCMV Armstrong and Clone13 infection.