Supporting data for "INTERACTION OF ADIOCYTES AND CANCER CELLS TO PROMOTE BREAST CANCER GROWTH IN CCL/CCR7 CHEMOKINE AXIS"

Cancer-associated adipocytes (CAAs) are one of the compositions in breast cancer tumor microenvironment (TME), which were smaller, fewer lipids, fewer differential markers, and had cancer-promoting effects. CAAs secrete several cytokines to influence cancer cells including hormones, interleukins, and chemokines. Studies revealed that CAAs can secrete CCL5 and CCL2 to promote breast cancer cells. However, study on the expression level and functions of CCL19 and CCR7 in breast cancer is limited. Thus, we aim to evaluate the interaction between adipocytes and breast cancer cells through the CCL/CCR7 chemokine axis.

癌相关脂肪细胞（CAAs）是乳腺癌肿瘤微环境（TME）的组成成分之一，其特征为体积较小、脂质含量较少、差异标记物较少，并具有促进癌细胞生长的作用。CAAs分泌多种细胞因子，以影响包括激素、白细胞介素和趋化因子在内的癌细胞。研究显示，CAAs能够分泌CCL5和CCL2以促进乳腺癌细胞的生长。然而，关于CCL19和CCR7在乳腺癌中的表达水平及其功能的研究尚显不足。因此，本研究的目的是通过CCL/CCR7趋化因子轴评估脂肪细胞与乳腺癌细胞之间的相互作用。