Human OA cartilages treated with ANGPTL3 mimetic LNA043 and placebo

Human OA patients subject to total knee replacement (TKR) were randomly selected and treated either LNA043 or placebo via intra-articular injection at 2hrs, 7days and 21days before surgery. The cartilage tissue were collected. Total RNA were extraced from both damaged and undamaged looking part of the tissue, and underwent gene expression profiling performed using next-generation sequencing on a Illumina platform. Paired design of both damaged and undamaged carilage tissue each from 7 and 9 patients treated with placebo and LNA043 were used in this study >>> Submitter declares that the raw data are unavailable for patient confidentiality reasons. <<<