Fragment-to-Lead Medicinal Chemistry Publications in 2023

This
Perspective summarizes successful fragment-to-lead (F2L) studies
that were published in 2023 and is the ninth installment in an annual
series. A tabulated summary of the relevant articles published in
2023 is provided (17 entries from 16 articles), and a comparison of
the target classes, screening methods, and overall fragment or lead
property trends for 2023 examples and for the combined entries over
the years 2015–2023 is discussed. In addition, we identify
several trends and innovations in the 2023 literature that promise
to further increase the success of fragment-based drug discovery (FBDD),
particularly in the areas of NMR and virtual screening, fragment library
design, and fragment linking.