Genomic Typing, Antimicrobial Resistance Gene, Virulence Factor and Plasmid Replicon Dataset for the Important Pathogenic Bacteria Staphylococcus aureus

Infections caused by diverse bacterial pathogens in both clinical and community environments pose a major global public health challenge. The increasing resistance of bacteria responsible for healthcare-associated infections to antimicrobial drugs has escalated into a critical threat, as highlighted by the World Health Organization. Certain groups or lineages of bacterial isolates, often referred to as "high-risk clones," play a key role in the dissemination of resistance within specific species.

Consequently, identifying and monitoring the spread of these clones, along with understanding the mechanisms through which they develop antibiotic resistance and improve their survival capabilities, is of utmost importance. Today, whole genome sequencing of relevant bacterial isolates is increasingly employed for these objectives, including epidemiological monitoring and the formulation of strategies to curb their spread. However, the accessibility and consistency of data obtained from genomic sequencing often present significant challenges for such research efforts.

In this dataset, we present the results of a genomic epidemiology analysis of 98,950 genomes of a dangerous bacterial pathogen Staphylococcus aureus obtained from NCBI Genbank database. Important typing information including multilocus sequence typing (MLST)-based sequence types (STs), clonal complexes (CC) and cgMLST profiles are presented. The presence of antimicrobial resistance and virulence genes, as well as plasmid replicons and CRISPR-Cas systems, within the genomes is also reported. 

These data will be useful for researchers in the field of S. aureus genomic epidemiology, resistance analysis and prevention measure development.