A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer

Expression of 276 genes was associated with OS at a false discovery rate (FDR) of < 0.05 in covariate-adjusted single gene analyses. The top five genes were TAP1, ZFHX4, CXCL9, FBN1, and PTGER3 (p ≪ 0.001). The best performing signature included 101 genes and for each SD difference in the gene expression score conferred a greater than two-fold increase in risk of death (HR = 2.35 [2.02, 2.71]; p ≪ 0.001). Median survival by quintile group was 9.5, 5.4, 3.8, 3.2 and 2.3 years. Expression of 513 genes was measured in formalin-fixed paraffin-embedded (FFPE) tumor tissue from 3,769 women with HGSOC. Regression-based and machine learning methods were used to develop a prognostic signature for OS. Prognostic models were trained on two thirds of the data and evaluated on the remaining third. Contributor: AOCS Group