Pharmacokinetic parameter values estimated in the patients with severe malaria compared to those from moderately severe malaria [15].

The moderate severe malaria parameter estimates are derived from the best model without considering covariates (for comparison with the current parameter estimates). Baseline = base+gradient(1)*time+gradient(2)*time2. Where time represents time post-start of L-arginine infusion. CL = clearance, V1 = central volume of distribution, V2 = peripheral volume of distribution, Q = intercompartmental clearance, BSV = between subject variability which was assumed to be log-normally distribution and expressed as a %, σ = residual variability (standard deviation).