Exosomal Long noncoding RNA MAGI2-AS3 and CCDC144NL-AS1 possibly promote oral squamous cell carcinoma development via PI3K-AKT-mTOR signal pathway

The lncRNA expression profiles were examined derived from serum exosomes (SEs) from patients with oral squamous cell carcinoma (OSCC) with lymph node metastasis (OSCC-LNM), OSCC with no LNM (OSCC-NLNM), oral leukoplakia (OL), postoperative metastasis and recurrence OSCC (PMPMROSCC) and healthy controls (HCs). Bioinformatics analysis was used to analyse differentially expressed lncRNAs (DE lncRNAs) and a total of 150 subjects were enrolled for RT-PCR verifications. The correlations of four lncRNAs and clinicopathologic factors, biochemical indexes were evaluated. MAGI2-AS3 and CCDC144NL-AS1 were overexpressed or silenced in oral cancer (OC) cells. The proliferation, invasion, and migration were evaluated to investigate the effect of MAGI2-AS3 and CCDC144NL-AS1 on the development of OSCC. The related proteins of PI3K-AKT-mTOR signal pathway were also detected.