Effect of metal ion on itaconic acid fermentability for Aspergillus terreus

Zn (?) and Fe (?) are the essential metal elements for the growth of microorganisms. It illustrated that more itaconic acid was achieved for 0.25 g/L ZnSO4·2H2O and 0.40 g/L FeSO4·2H2O than the control with 0.15 g/L ZnSO4·2H2O and 0.16 g/L FeSO4·2H2O after single factor assays for Aspergillus terreus.We furhter carried out transcriptome assays to uncover molecular mechanism of the enhanced itaconic acid fermentability for A. terreus with metal ion.Therefore, our study would provide a reference metal ion concentration ratio for itaconic and other biochemicals production. Overall design: Comparative of gene expression profiling using RNA-seq data between the control groups and the optimized metal ion groups for the wild Aspergillus terreus.