Short-term fasting releases the hematopoietic brake to promote bone marrow erythropoiesis

How our body adapts erythropoiesis to fluctuating nutrient availability is an unanswered question in hematopoietic development. Here, we demonstrate that short-term fasting triggers a sustained increase in red blood cell (RBC) production by remodeling the developmental trajectory of bone marrow megakaryocyte-erythroid progenitors (MEPs). Overall design: We sorted megakaryocyte–erythroid progenitor cell from bone marrow of 6h fasted mice and control mice for bulk RNA-seq to investigate the molecular influence which fasting poses on erythropoiesis.