Assessing the Relationship between Low-Calorie Sweetener Use and Quality of Life Measures in Adults with Type 1 Diabetes

Less than third of the adults with type 1 diabetes (T1D) in US achieve American Diabetes Association (ADA) goals for HbA1c; i.e. HbA1c <7% for adults without significant comorbidities. Despite advances in diabetes technologies and therapeutics in recent years, postprandial hyperglycemia has been a major contributor of elevated HbA1c .Amount of carbohydrate intake negatively affect the postprandial glycemia and uncontrolled diabetes have a negative impact of quality of life (QOL) and overall well-being of patients with T1D. QOL is an important factor in diabetes management and has a positive impact on diabetes outcomes. In parallel, optimal glycemic control which may be achieved with decreased carbohydrate intake has been shown to improve QOL in patients with diabetes. For some people with diabetes who are accustomed to regularly consuming sugar-sweetened products, low-calorie sweeteners (LCS) may be an acceptable substitute for nutritive sweeteners. Reducing carbohydrate intake and substituting with LCS may have some role in improving postprandial glycemic control and related improvement of QOL in patients with diabetes. However, role of LCS on QOL has not been studied in adults with T1D therefore, we propose this study to assess the relationship between LCS and QOL measures in adults with T1D.

在美国，患有1型糖尿病（T1D）的成年人中，不足三分之一的人能够达到美国糖尿病协会（ADA）对于HbA1c的控制目标；即，对于无显著合并症的成年人而言，HbA1c应低于7%。尽管近年来糖尿病技术和治疗方法的进步显著，但餐后高血糖仍是对HbA1c水平升高的主要贡献因素。碳水化合物的摄入量对餐后血糖有负面影响，而未得到有效控制的糖尿病则对1型糖尿病患者的生命质量（QOL）和整体福祉产生消极影响。生命质量是糖尿病管理中的重要因素，并对糖尿病的预后产生积极影响。与此同时，通过减少碳水化合物摄入量可能实现的最佳血糖控制已被证明能够改善糖尿病患者的生命质量。对于一些习惯于定期食用糖分甜味产品的糖尿病患者而言，低热量甜味剂（LCS）可能成为营养性甜味剂的合适替代品。减少碳水化合物摄入并替换为LCS可能在改善糖尿病患者餐后血糖控制和相关生命质量方面发挥一定作用。然而，LCS对1型糖尿病成人生命质量的影响尚未得到研究，因此，我们提出此项研究，旨在评估LCS与1型糖尿病成人生命质量指标之间的关系。