Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1

Structure of human ceramide synthase 6 (CerS6) in complex with N-palmitoyl fumonisin B1 Descriptor: (2~{R})-2-[2-[(5~{R},6~{R},7~{S},9~{S},11~{R},16~{R},18~{S},19~{S})-6-[(3~{R})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-19-(hexadecanoylamino)-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Pascoa, T.C, Pike, A.C.W, Chi, G, Stefanic, S, Quigley, A, Chalk, R, Mukhopadhyay, S.M.M, Venkaya, S, Dix, C, Moreira, T, Tessitore, A, Cole, V, Chu, A, Elkins, J.M, Pautsch, A, Schnapp, G, Carpenter, E.P, Sauer, D.B. Deposit date: 2023-10-26 Release date: 2024-11-13 Last modified: 2025-03-26 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis of the mechanism and inhibition of a human ceramide synthase. Nat.Struct.Mol.Biol., 32, 2025