Single-cell RNA-seq reveals the difference between Schwann cells in dorsal root ganglion and sciatic nerve

Schwann cells are important glial cells in peripheral nervous system. In this study, we performed single cell RNA-sequencing (scRNA-seq) analysis of Schwann cells exist in both dorsal root ganglion(DRG) and sciatic nerve.We categorized DRG and sciatic nerve Schwann cells into different subtypes,and found common subtypes and different subtypes.In addition, we discovered the proliferation and migration ability of Schwann cells were distinct in different tissues.Our current study revealed the distinctive characteristics of Schwann cells in DRG and sciatic nerve. The Schwann cell mRNA profiles of DRG and sciatic nerve at 1-day-old and 8-week-old SD rats were established by 10x genomic analysis.