LIPC dimer hydrolyses TAG to DAG and FA

Fatty acids (FAs) are used as energy substrates and are stored as triglycerides. Triacylglycerol (TAG) has to be cleaved by lipases to be able to move in and out of cells for usage. Hepatic triacylglycerol lipase (LIPC) is one of several enzymes that catalyses the hydrolysis of TAGs to free fatty acids (FAs) and diacylglycerol (DAG) (Hegele et al. 1993, Santamarina-Fojo et al. 2004). Defects in LIPC can cause hepatic lipase deficiency (HL deficiency; MIM:614025), a disorder characterised by premature atherosclerosis and abnormal circulating lipoproteins (Hegele et al. 1992, 1993).

脂肪酸（FAs）作为能量底物被利用，并以甘油三酯的形式储存。三酰甘油（TAG）需经脂肪酶分解，方能进出细胞进行利用。肝三酰甘油脂肪酶（LIPC）是催化TAG水解为游离脂肪酸（FAs）和二酰甘油（DAG）的多种酶之一（Hegele et al. 1993, Santamarina-Fojo et al. 2004）。LIPC基因的缺陷可导致肝脂肪酶缺乏症（HL缺乏症；MIM:614025），该病症以早发性动脉粥样硬化和异常的循环脂蛋白为特征（Hegele et al. 1992, 1993）。