Changes in inflammatory lipids during first 48h of pneumonic plague.

C57BL/6J mice were infected with 10 x the LD50 of Y. pestis KIM5+ and lungs were harvested at 6, 12, 24, 36, and 48 h post-infection (n = 5). Total lipids were isolated from homogenized lungs and lipids were quantified by LC-MS. Significant changes in lipid concentrations were observed in at least one time point for 63 lipids. Lipids that were below the limit of detection for all time points were excluded from statistical analysis. (XLSX)