PACIFIC dataset_main figures

The aim of the PACIFIC study is to compare 46 AIEC bacteria isolated from Crohn's patients in France and Hong Kong between 2017 and 2022. Their adhesion and invasion to intestinal epithelial cells phenotype was tested. Colonisation of the gut of a mouse model mimicking Crohn's disease by 4 strains isolated in France and 4 strains isolated in Hong Kong was compared. The sequencing of 46 strains was carried out and the raw data used for the genomic analyses is compiled in a file. The isolated strains were also tested for antibiotic resistance and sensitivity to a cocktail of phages.

PACIFIC研究旨在对比2017年至2022年间，从法国与香港克罗恩病（Crohn's disease）患者体内分离得到的46株AIEC细菌（Adherent-Invasive Escherichia coli）。研究团队检测了这些菌株对肠上皮细胞的粘附与侵袭表型；对比了分别从法国和香港分离的各4株菌株在模拟克罗恩病的小鼠模型肠道内的定植能力；完成了全部46株菌株的全基因组测序，用于基因组分析的原始数据已汇总至文件中；此外还对分离得到的菌株开展了抗生素耐药性以及对噬菌体鸡尾酒的敏感性检测。

搜集汇总

背景与挑战

背景概述

PACIFIC数据集包含46株从法国和香港克罗恩病患者中分离的AIEC细菌的比较研究数据，涵盖细菌的粘附侵袭能力、小鼠模型肠道定植实验、基因组测序及抗生素耐药性测试。数据来源于2017至2022年的实验和分析，旨在比较不同地区菌株的特性。