Changes in the transcriptome, proteome and phosphoproteome in a cardiomyocyte model of nitroxidative stress. Rattus norvegicus

Cells adapt to stress via changes in gene expression, protein degradation and PTMs. However, compared to regulations via PTMs and protein turnover, gene expression is a relatively slow process. We used a multi-omic approach to investigate different dynamics of transcripts, proteins and phosphoproteins during nitroxidative stress. Overall design: This study was performed in biological triplicates for rat cardiomyocytes