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A CRISPR-Cas9 Knockout Screening Identifies IRF2 as a Key Driver of OAS3/RNase L-Mediated RNA Decay During Viral Infection

NIAID Data Ecosystem2026-05-02 收录

病毒感染与宿主免疫

RNA降解机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1125024 数据链接链接失效反馈

官方服务：

资源简介：

CRISPR KO screening and IRF2 ChIP-seq

应用场景：

创建时间：

2024-06-17

病毒-宿主相互作用

RNA降解机制

HEK293T ishXrn1 cells were treated with doxycycline for 3-4 days to induce knock down of Xrn1, then transfected with PA-X from the influenza A/Puerto Rico/8/1984 (H1N1) ("PR8") or A/Perth/16/2009 (H3N

NIAID Data Ecosystem40

Mammalian microRNAs predominantly act to decrease target mRNA levels

miRNA靶基因调控

RNA降解机制

MicroRNAs (miRNAs) are endogenous ~22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regu

NIAID Data Ecosystem40

ExtFig3E_RACE_BCAP31_R2_LG277.tif

RNA降解机制

"5RACE技术应用"

HEK293T ishXrn1 cells were treated with doxycycline for 3-4 days to induce knock down of Xrn1, then transfected with the luciferase reporters containing 99 bp insertions from the BCAP1, INSIG1, SLC7A5

NIAID Data Ecosystem40

Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals [ncRNA-Seq]

RNA降解机制

转录组稳定性

Here we present complete genomic and biochemical annotations of the signals required for RNA degradation by the dsRNA specific ribonuclease III (Rnt1p) and examine its impact on transcriptome stabilit

NIAID Data Ecosystem40

ExtFig4A_RACE_D108A_R3_LG320_annotated.tif

RNA降解机制

"5RACE转录本鉴定"

NIAID Data Ecosystem40