Even the latest generation of base editor (BE3) causes unwanted indels and non-C-to-T substitutions, compromising the fidelity of base editing outcome. Here we report a enhanced base editing system. T

NIAID Data Ecosystem30

Homo sapiens Raw sequence reads of IminiBEs and SIminiBEs

基因工程工具开发

碱基编辑器优化

IscB is likely the ancestor of CRISPR Cas9 that shares a similar domain organization. IscB nuclease or nickase could be harnessed for genome editing. Particularly the small size of IscB satisfies the

NIAID Data Ecosystem20

Expanded repertoire of RNA-editing-based detection for RNA binding protein interactions (4)

RNA相互作用检测

碱基编辑器优化

RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editin

NIAID Data Ecosystem40

Cytidine and adenine base editors with improved editing efficiencies in mammalian cells

碱基编辑器优化

哺乳动物细胞基因组编辑与测序

We created AncBE4max, BE4max, and ABEmax tosubstantially expand the capabilities of both cytidine and adenine base editing and represent current state-of-the-art mammalian cell base editors.

NIAID Data Ecosystem30

Towards optimizing diversifying base editors for high-throughput mutational scanning studies

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