Evaluation for effects on anticancer efficacy and patient’s QOL from dosage adjustment caused by skin toxicity in Panitumumab treatment for Metastatic Colorectal Cancer

Interventions: mFOLFOX6+Panitumumab therapy is performed until PD. And dosage of Panitumumab is adjusted according to skin toxicity measured by self-check sheet before each therapy. Oxaliplatin 85mg/m2 5FU 400mg/m2 bolus, 2400mg/m2 continuous drip Levofolinate 200mg/m2 Panitumumab 6mg/kg Primary outcome(s): Progression-free survival Study Design: Single arm Non-randomized