Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog

Protein Data Bank Japan2025-03-26 更新2026-03-21 收录

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Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog Descriptor: 1-{5-oxo-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N-(pyridin-2-ylmethyl)methanesulfonamide, Hepatocyte growth factor receptor Authors: Soisson, S.M, Northrup, A, Rickert, K, Patel, S, Allison, T. Deposit date: 2013-01-23 Release date: 2013-12-11 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. J.Med.Chem., 56, 2013

创建时间：

2013-01-23