Inhibition of neuronal nitric oxide synthase (nNOS), an enzyme implicated in neurodegenerative disorders, is an attractive strategy for treating or preventing these diseases. We previously developed s
This dataset contains raw and processed data supporting the generation and characterization of a C9orf72 loss-of-function (LOF) zebrafish (Danio rerio) model and a complementary Caenorhabditis elegans
AimTo explore the inhibitory effect of hirsutine (HS) against amyloid β-protein (Aβ) fibrillogenesis, as well as its disintegrating effect on mature fibrils.MethodsAn in vitro model of amyloid fibrill
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration Descriptor: Mitogen-activated protein kinase 10, N-[4-
While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathological feature
