Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice.

We investigated the effect of SMAD4 loss in KPC PDAC tumors Overall design: Single-cell RNA-sequencing (scRNA-seq) of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC (i.e. KRASG12D; p53 mutant) organoids in nu/nu mice. These data have been sequenced twice and the 2 sequenced datasets were merged in the final paper. Batch 1 (SLX-21116) has reads from 2 lanes, and Batch 2 (SLX-21289) has reads from 1 lane. 9 samples in total - 3 KPC SMAD4 WT; 6 KPC SMAD4 KO