eIF2α phosphorylation-mediated translational regulation is crucial for global translation repression by various stresses, including the unfolded protein response (UPR). However, translational control

NIAID Data Ecosystem40

Figure4_2B_Nup54-mEGFP494(1)_starved

核孔复合体

细胞应激响应

The Inner Ring Nup Nup54 is reorganized with respect to the NPC after starvation.

Figshare2020-12-06 更新30

ICG-001 activates a series of ER stress response genes in monocyte derived macrophages (MDMs)

细胞应激响应

Wnt信号通路调控

By screening a target-focused Wnt-sgnaling small compound library we identified the Wnt-modulator ICG-001 as inihibitory for activating the mitochondrial fission protein Drp1. To explore how ICG-001 m

NIAID Data Ecosystem50

Serine mistranslation induces the integrated stress response through the P1 stalk

翻译错误机制

细胞应激响应

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that support robust and accurate protein synthesis. A rapidly expanding number of studies show that mutations in aaRSs lead to multiple human d

NIAID Data Ecosystem30

Flow cytometry measurements

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