Frequency and relative effect size of haplotype between rs11878604 (SNP) and rs8102683 (CNP).

¶Haplotypes consisting of alleles at rs11878604 [T/C] and haplotypic copy numbers at rs8102683 [0/1/2].*Haplotype frequencies and relative effect sizes are jointly evaluated using a haplotype-specific linear regression model as described previously [27]. All model parameters were estimated using a standard EM (expectation-maximization) algorithm [28].†Variance explained by these six haplotypes and its significance was assessed in the standard ANOVA (analysis of variance) framework.