Effects of dizocilpine, midazolam and their co-application on the trimethyltin (TMT)-induced rat model of neurodegeneration

The aim of this study was to explore the effect of NMDA receptor antagonist dizocilpine (MK-801) and GABAA receptor potentiator midazolam on the cognitive deficit and hippocampal cell loss induced by TMT and to investigate whether their co-application is associated with enhanced neuroprotective effects.
Co-application of MK-801 and midazolam provided mild neuroprotective effect with respect to the histological parameters, while the compounds alone were largely ineffective. All three neuroprotective treatments induced similar degree of therapeutic effect in Morris water maze.