Thal-Kak Multiple Sequence Alignment Databases

A collection of prebuilt protein sequence databases for multiple sequence alignment (MSA) search. MSAs are the main input of protein structure prediction and are also used to study conservation, coevolution and protein function. The nine databases, in the native formats of MMseqs2 and HH-suite, derive from UniProt UniRef100 (release 2026_01), the reduced BFD, MGnify (release 2024_04), EnVhogDB and the Logan protein catalogue from the NCBI Sequence Read Archive. The sequences of UniRef100, MGnify and the reduced BFD were re-clustered, EnVhogDB was re-clustered at its upstream standard level, an...